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Saturday, July 9, 2016
Non-response to daclatasvir and asunaprevir therapy in patients co-infected with hepatitis C virus genotypes 1 and 2.
agents (DAAs) for hepatitis C virus (HCV) have been developed such as
combined daclatasvir (DCV) and asunaprevir (ASV) treatment. This
typically enables HCV serotype 1 patients to achieve a high sustained
virological response (SVR) rate, but a small number of such patients
fail to respond to therapy. We investigated three HCV patients who
showed no response to DCV and ASV therapy. HCV genotyping was performed
in the three patients using nested polymerase chain reaction (PCR) and
PCR direct sequencing in the core region of the HCV genome. All three
patients possessed HCV serotype 1, and no mutations were identified in
either the NS3 or NS5A region. The three patients were shown to be
co-infected with HCV genotypes 1 and 2 because genotypes 2a and 2b were
also identified. This is the first report into the failed response to
DCV and ASV therapy in patients co-infected with HCV genotypes 1 and 2.